Treatment of amitriptyline intoxications by extended high cut-off dialysis

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چکیده

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Treatment of amitriptyline intoxications by extended high cut-off dialysis

Antidepressants, especially amitriptyline, are among the most frequent drug classes involved in intoxications. Despite its small molecular weight, amitriptyline is not considered to be eliminated by extracorporeal treatment methods due to its high protein binding and large volume of distribution. New high cut-off dialysers have so far not been used for removal of amitriptyline. We report two ca...

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Treatment of amitriptyline intoxications by extended high cut-off dialysis: report of two cases

Antidepressants, especially amitriptyline, are among themost frequent drug classes involved in intoxications. Despite its small molecular weight, amitriptyline is not considered to be eliminated by extracorporeal treatmentmethods due to its high protein binding and large volume of distribution. New high cut-off dialysers have so far not been used for removal of amitriptyline. We report two case...

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This study investigates the importance of selecting an appropriate cut-off frequency in the SWAN model when it is applied to areas with limited fetches. In SWAN, the cut-off frequency is a constant value set by user in the model, and its appropriate selection plays an important role in the accuracy and optimization of the wave model; very high value increases the computational cost and might le...

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Saving two lives with one dialysis treatment Successful treatment of life threatening diphenhydramine intoxication by intermittent hemodialysis using a high cut-off membrane

Hemodialysis is the extracorporeal treatment of choice for various life-threatening intoxications, with the exception of highly protein-bound substances, which are preferably removed by charcoal hemoperfusion. This technique, however, is limited by its availability and its significant side effects. We present a potentially lifethreatening diphenhydramine (DPH) overdose in a stuporous female pat...

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ژورنال

عنوان ژورنال: Clinical Kidney Journal

سال: 2015

ISSN: 2048-8505,2048-8513

DOI: 10.1093/ckj/sfv094